Mirin: identifying microRNA regulatory modules in protein–protein interaction networks | Zendy

Ken-Chi Yang | Zendy; ChiaLang Hsu | Zendy; Chen-Ching Lin | Zendy; HsuehFen Juan | Zendy; HsuanCheng Huang | Zendy

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Mirin: identifying microRNA regulatory modules in protein–protein interaction networks

Author(s) -

Ken-Chi Yang,

ChiaLang Hsu,

Chen-Ching Lin,

HsuehFen Juan,

HsuanCheng Huang

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu306

Subject(s) - microrna , computational biology , protein–protein interaction , biology , gene , interaction network , genetics

Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer.

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