TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception | Zendy

Amir R. Kermany | Zendy; Laure Ségurel | Zendy; Tiffany R. Oliver | Zendy; Molly Przeworski | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception

Author(s) -

Amir R. Kermany,

Laure Ségurel,

Tiffany R. Oliver,

Molly Przeworski

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu159

Subject(s) - aneuploidy , genotyping , trisomy , biology , snp , chromosome , genetics , computational biology , computer science , single nucleotide polymorphism , genotype , gene

An estimated 10-30% of clinically recognized conceptions are aneuploid, leading to spontaneous miscarriages, in vitro fertilization failures and, when viable, severe developmental disabilities. With the ongoing reduction in the cost of genotyping and DNA sequencing, the use of high-density single nucleotide polymorphism (SNP) markers for clinical diagnosis of aneuploidy and biomedical research into its causes is becoming common practice. A reliable, flexible and computationally feasible method for inferring the sources of aneuploidy is thus crucial.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research