Optimal metabolic route search based on atom mappings | Zendy

Mario Latendresse | Zendy; Markus Krummenacker | Zendy; Peter D. Karp | Zendy

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Optimal metabolic route search based on atom mappings

Author(s) -

Mario Latendresse,

Markus Krummenacker,

Peter D. Karp

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu150

Subject(s) - computer science , atom (system on chip) , algorithm , programming language , parallel computing

A key computational problem in metabolic engineering is finding efficient metabolic routes from a source to a target compound in genome-scale reaction networks, potentially considering the addition of new reactions. Efficiency can be based on many factors, such as route lengths, atoms conserved and the number of new reactions, and the new enzymes to catalyze them, added to the route. Fast algorithms are needed to systematically search these large genome-scale reaction networks.

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