Induction of T-cell memory by a dendritic cell vaccine: a computational model | Zendy

Francesco Pappalardo | Zendy; Marzio Pennisi | Zendy; Alessia Ricupito | Zendy; Francesco Topputo | Zendy; Matteo Bellone | Zendy

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Induction of T-cell memory by a dendritic cell vaccine: a computational model

Author(s) -

Francesco Pappalardo,

Marzio Pennisi,

Alessia Ricupito,

Francesco Topputo,

Matteo Bellone

Publication year - 2014

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btu059

Subject(s) - cytotoxic t cell , context (archaeology) , in silico , boosting (machine learning) , vaccination , antigen , t cell , dendritic cell , immunology , computer science , biology , computational biology , immune system , in vitro , machine learning , genetics , paleontology , gene

Although results from phase III clinical trials substantially support the use of prophylactic and therapeutic vaccines against cancer, what has yet to be defined is how many and how frequent boosts are needed to sustain a long-lasting and protecting memory T-cell response against tumor antigens. Common experience is that such preclinical tests require the sacrifice of a relatively large number of animals, and are particularly time- and money-consuming.

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