Open AccessSubclonal variant calling with multiple samples and prior knowledge
Author(s) -
Moritz Gerstung,
Elli Papaemmanuil,
Peter J. Campbell
Publication year - 2014
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btt750
Subject(s) - biology , genetics , computational biology , mutation , gene , probabilistic logic , point mutation , cancer , computer science , artificial intelligence
Targeted resequencing of cancer genes in large cohorts of patients is important to understand the biological and clinical consequences of mutations. Cancers are often clonally heterogeneous, and the detection of subclonal mutations is important from a diagnostic point of view, but presents strong statistical challenges.
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