Accessibility of microRNA binding sites in metastable RNA secondary structures in the presence of SNPs | Zendy

Luke Day | Zendy; Ouala Abdelhadi Ep Souki | Zendy; Andreas Albrecht | Zendy; Kathleen Steinhöfel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Accessibility of microRNA binding sites in metastable RNA secondary structures in the presence of SNPs

Author(s) -

Luke Day,

Ouala Abdelhadi Ep Souki,

Andreas Albrecht,

Kathleen Steinhöfel

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt695

Subject(s) - metastability , single nucleotide polymorphism , snp , microrna , messenger rna , untranslated region , rna , computational biology , nucleic acid secondary structure , binding site , genetics , nucleotide , context (archaeology) , biology , chemistry , gene , genotype , organic chemistry , paleontology

We study microRNA (miRNA) bindings to metastable RNA secondary structures close to minimum free energy conformations in the context of single nucleotide polymorphisms (SNPs) and messenger RNA (mRNA) concentration levels, i.e. whether features of miRNA bindings to metastable conformations could provide additional information supporting the differences in expression levels of the two sequences defined by a SNP. In our study, the instances [mRNA/3'UTR; SNP; miRNA] were selected based on strong expression level analyses, SNP locations within binding regions and the computationally feasible identification of metastable conformations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research