Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data
Author(s) -
Sebastian M. Waszak,
Helena Kilpinen,
Andreas R. Gschwind,
Andrea Orioli,
Sunil K. Raghav,
Robert M. Witwicki,
Eugenia Migliavacca,
Alisa Yurovsky,
Tuuli Lappalainen,
Nouria Hernandez,
Alexandre Reymond,
Emmanouil T. Dermitzakis,
Bart Deplancke
Publication year - 2013
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btt667
Subject(s) - biology , computational biology , dna sequencing , chromatin immunoprecipitation , genetics , identification (biology) , single cell sequencing , allele , dna , gene , mutation , exome sequencing , gene expression , promoter , botany
High-throughput sequencing technologies enable the genome-wide analysis of the impact of genetic variation on molecular phenotypes at unprecedented resolution. However, although powerful, these technologies can also introduce unexpected artifacts.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom