The functional therapeutic chemical classification system | Zendy

Samuel Croset | Zendy; John P. Overington | Zendy; Dietrich RebholzSchuhmann | Zendy

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The functional therapeutic chemical classification system

Author(s) -

Samuel Croset,

John P. Overington,

Dietrich RebholzSchuhmann

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt628

Subject(s) - chembl , computer science , drug repositioning , semantics (computer science) , ontology , repurposing , resource (disambiguation) , information retrieval , drug discovery , artificial intelligence , drug , bioinformatics , programming language , medicine , ecology , philosophy , computer network , epistemology , psychiatry , biology

Drug repositioning is the discovery of new indications for compounds that have already been approved and used in a clinical setting. Recently, some computational approaches have been suggested to unveil new opportunities in a systematic fashion, by taking into consideration gene expression signatures or chemical features for instance. We present here a novel method based on knowledge integration using semantic technologies, to capture the functional role of approved chemical compounds.

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