Open AccessDiscretized Gaussian mixture for genotyping of microsatellite loci containing homopolymer runs
Author(s) -
Hongseok Tae,
DongYun Kim,
John F. McCormick,
Robert E. Settlage,
Harold R. Garner
Publication year - 2013
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btt595
Subject(s) - microsatellite , genotyping , sequence (biology) , computer science , algorithm , genetics , biology , computational biology , genotype , allele , gene
Inferring lengths of inherited microsatellite alleles with single base pair resolution from short sequence reads is challenging due to several sources of noise caused by the repetitive nature of microsatellites and the technologies used to generate raw sequence data.
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