The code structure of the p53 DNA-binding domain and the prognosis of breast cancer patients | Zendy

Keiko Sato | Zendy; Toshihide Hara | Zendy; Masanori Ohya | Zendy

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The code structure of the p53 DNA-binding domain and the prognosis of breast cancer patients

Author(s) -

Keiko Sato,

Toshihide Hara,

Masanori Ohya

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt497

Subject(s) - breast cancer , dna , gene , cancer , biology , dna binding domain , mutation , computational biology , domain (mathematical analysis) , dna sequencing , clinical significance , genetics , cancer research , medicine , mathematics , transcription factor , mathematical analysis

The tumor-suppressor gene TP53 mutations are diverse in the central region encoding the DNA-binding domain. It has not been clear whether the prognostic significance for survival in breast cancer patients is the same for all types of mutations. Are there specific types of mutations carrying a worse prognosis? To understand the correlation between the mutations in the gene encoding the DNA-binding domain and the prognosis of breast cancer, we studied the code structure of the DNA-binding domain of breast cancer patients by using various artificial codes in information transmission.

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