Optimizing a global alignment of protein interaction networks | Zendy

Leonid Chindelevitch | Zendy; Cheng-Yu Ma | Zendy; Chung-Shou Liao | Zendy; Bonnie Berger | Zendy

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Optimizing a global alignment of protein interaction networks

Author(s) -

Leonid Chindelevitch,

Cheng-Yu Ma,

Chung-Shou Liao,

Bonnie Berger

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt486

Subject(s) - computer science , robustness (evolution) , pairwise comparison , heuristic , multiple sequence alignment , protein interaction networks , biological network , software , network topology , sequence alignment , data mining , theoretical computer science , machine learning , artificial intelligence , bioinformatics , protein–protein interaction , biology , biochemistry , genetics , gene , peptide sequence , programming language , operating system

The global alignment of protein interaction networks is a widely studied problem. It is an important first step in understanding the relationship between the proteins in different species and identifying functional orthologs. Furthermore, it can provide useful insights into the species' evolution.

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