nCal: an R package for non-linear calibration | Zendy

Youyi Fong | Zendy; Krisztian Sebestyen | Zendy; Xuesong Yu | Zendy; Peter B. Gilbert | Zendy; Steve Self | Zendy

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nCal: an R package for non-linear calibration

Author(s) -

Youyi Fong,

Krisztian Sebestyen,

Xuesong Yu,

Peter B. Gilbert,

Steve Self

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt456

Subject(s) - calibration , computer science , mathematics , statistics

Non-linear calibration is a widely used method for quantifying biomarkers wherein concentration-response curves estimated using samples of known concentrations are used to predict the biomarker concentrations in the samples of interest. The R package nCal fills an important gap in the open source, stand-alone software for performing non-linear calibration. For curve fitting, nCal provides a new implementation of a robust, Bayesian hierarchical five-parameter logistic model. nCal supports a simple graphical user interface that can be used by laboratory scientists, and contains functionality for importing data from the multiplex bead array assay instrumentation.

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