Exploring the role of human miRNAs in virus–host interactions using systematic overlap analysis | Zendy

Zhenpeng Li | Zendy; Xiuliang Cui | Zendy; Fei Li | Zendy; Peng Li | Zendy; Ming Ni | Zendy; Shengqi Wang | Zendy; Xiaochen Bo | Zendy

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Exploring the role of human miRNAs in virus–host interactions using systematic overlap analysis

Author(s) -

Zhenpeng Li,

Xiuliang Cui,

Fei Li,

Peng Li,

Ming Ni,

Shengqi Wang,

Xiaochen Bo

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt391

Subject(s) - biology , microrna , interactome , computational biology , virus , viral replication , genetics , gene

Human miRNAs have recently been found to have important roles in viral replication. Understanding the patterns and details of human miRNA interactions during virus-host interactions may help uncover novel antiviral therapies. Based on the abundance of knowledge available regarding protein-protein interactions (PPI), virus-host protein interactions, experimentally validated human miRNA-target pairs and transcriptional regulation of human miRNAs, it is possible to explore the complex regulatory network that exists between viral proteins and human miRNAs at the system level.

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