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Quikr: a method for rapid reconstruction of bacterial communities via compressive sensing
Author(s) -
David Koslicki,
Simon Foucart,
Gail Rosen
Publication year - 2013
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btt336
Subject(s) - computer science , python (programming language) , metagenomics , data mining , matlab , classifier (uml) , amplicon , software , levenshtein distance , machine learning , artificial intelligence , pattern recognition (psychology) , biology , polymerase chain reaction , biochemistry , gene , programming language , operating system
Many metagenomic studies compare hundreds to thousands of environmental and health-related samples by extracting and sequencing their 16S rRNA amplicons and measuring their similarity using beta-diversity metrics. However, one of the first steps--to classify the operational taxonomic units within the sample--can be a computationally time-consuming task because most methods rely on computing the taxonomic assignment of each individual read out of tens to hundreds of thousands of reads.

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