Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci | Zendy

Fabian A. Buske | Zendy; Denis C. Bauer | Zendy; John S. Mattick | Zendy; Timothy L. Bailey | Zendy

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Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci

Author(s) -

Fabian A. Buske,

Denis C. Bauer,

John S. Mattick,

Timothy L. Bailey

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt315

Subject(s) - computational biology , computer science , source code , sequence (biology) , genomics , selection (genetic algorithm) , code (set theory) , biology , genetics , genome , gene , artificial intelligence , set (abstract data type) , programming language

At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account.

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