EpiCombFlu: exploring known influenza epitopes and their combination to design a universal influenza vaccine | Zendy

Varun Jaiswal | Zendy; Sree K. Chanumolu | Zendy; Pankaj Sharma | Zendy; Rajinder Singh Chauhan | Zendy; Chittaranjan Rout | Zendy

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EpiCombFlu: exploring known influenza epitopes and their combination to design a universal influenza vaccine

Author(s) -

Varun Jaiswal,

Sree K. Chanumolu,

Pankaj Sharma,

Rajinder Singh Chauhan,

Chittaranjan Rout

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt304

Subject(s) - epitope , virology , pandemic , vaccination , influenza vaccine , antigenic drift , antigenic shift , population , seasonal influenza , biology , antigen , influenza a virus , immunology , medicine , virus , environmental health , covid-19 , disease , pathology , infectious disease (medical specialty)

Influenza is responsible for half a million deaths annually, and vaccination is the best preventive measure against this pervasive health problem. Influenza vaccines developed from surveillance data of each season are strain-specific, and therefore, are unable to provide protection against pandemic strains arising from antigenic shift and drift. Seasonal epidemics and occasional pandemics of influenza have created a need for a universal influenza vaccine (UIV). Researchers have shown that a combination of conserved epitopes has the potential to be used as a UIV.

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