DrugMap Central: an on-line query and visualization tool to facilitate drug repositioning studies | Zendy

Changhe Fu | Zendy; Guangxu Jin | Zendy; Junfeng Gao | Zendy; Rui Zhu | Zendy; Efren Ballesteros-villagrana | Zendy; Stephen T.C. Wong | Zendy

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DrugMap Central: an on-line query and visualization tool to facilitate drug repositioning studies

Author(s) -

Changhe Fu,

Guangxu Jin,

Junfeng Gao,

Rui Zhu,

Efren Ballesteros-villagrana,

Stephen T.C. Wong

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt279

Subject(s) - computer science , drug , drug repositioning , visualization , information retrieval , food and drug administration , data science , data mining , risk analysis (engineering) , pharmacology , medicine

Systematic studies of drug repositioning require the integration of multi-level drug data, including basic chemical information (such as SMILES), drug targets, target-related signaling pathways, clinical trial information and Food and Drug Administration (FDA)-approval information, to predict new potential indications of existing drugs. Currently available databases, however, lack query support for multi-level drug information and thus are not designed to support drug repositioning studies. DrugMap Central (DMC), an online tool, is developed to help fill the gap. DMC enables the users to integrate, query, visualize, interrogate, and download multi-level data of known drugs or compounds quickly for drug repositioning studies all within one system.

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