CellAging: a tool to study segregation and partitioning in division in cell lineages of Escherichia coli | Zendy

Antti Häkkinen | Zendy; Anantha-Barathi Muthukrishnan | Zendy; André Mora | Zendy; José Fonseca | Zendy; André S. Ribeiro | Zendy

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CellAging: a tool to study segregation and partitioning in division in cell lineages of Escherichia coli

Author(s) -

Antti Häkkinen,

Anantha-Barathi Muthukrishnan,

André Mora,

José Fonseca,

André S. Ribeiro

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt194

Subject(s) - cell division , escherichia coli , division (mathematics) , biology , fluorescence , segmentation , lineage (genetic) , fluorescence microscope , cell , computational biology , biological system , microbiology and biotechnology , artificial intelligence , computer science , genetics , gene , optics , physics , mathematics , arithmetic

Cell division in Escherichia coli is morphologically symmetric. However, as unwanted protein aggregates are segregated to the cell poles and, after divisions, accumulate at older poles, generate asymmetries in sister cells' vitality. Novel single-molecule detection techniques allow observing aging-related processes in vivo, over multiple generations, informing on the underlying mechanisms.

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