INstruct: a database of high-quality 3D structurally resolved protein interactome networks
Author(s) -
Michael J. Meyer,
Jishnu Das,
Xiujuan Wang,
Haiyuan Yu
Publication year - 2013
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btt181
Subject(s) - interactome , computer science , interface (matter) , visualization , inference , upload , database , information retrieval , data mining , world wide web , biology , artificial intelligence , gene , genetics , bubble , maximum bubble pressure method , parallel computing
INstruct is a database of high-quality, 3D, structurally resolved protein interactome networks in human and six model organisms. INstruct combines the scale of available high-quality binary protein interaction data with the specificity of atomic-resolution structural information derived from co-crystal evidence using a tested interaction interface inference method. Its web interface is designed to allow for flexible search based on standard and organism-specific protein and gene-naming conventions, visualization of protein architecture highlighting interaction interfaces and viewing and downloading custom 3D structurally resolved interactome datasets.
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