ELOPER: elongation of paired-end reads as a pre-processing tool for improved de novo genome assembly | Zendy

David H. Silver | Zendy; Shay BenElazar | Zendy; Alexei Bogoslavsky | Zendy; Itai Yanai | Zendy

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ELOPER: elongation of paired-end reads as a pre-processing tool for improved de novo genome assembly

Author(s) -

David H. Silver,

Shay BenElazar,

Alexei Bogoslavsky,

Itai Yanai

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt169

Subject(s) - contig , sequence assembly , computer science , pairing , process (computing) , genome , computational biology , software , biology , genetics , programming language , transcriptome , physics , gene , gene expression , superconductivity , quantum mechanics

Paired-end sequencing resulting in gapped short reads is commonly used for de novo genome assembly. Assembly methods use paired-end sequences in a two-step process, first treating each read-end independently, only later invoking the pairing to join the contiguous assemblies (contigs) into gapped scaffolds. Here, we present ELOPER, a pre-processing tool for pair-end sequences that produces a better read library for assembly programs.

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