Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation | Zendy

Bogdan Paşaniuc | Zendy; Sriram Sankararaman | Zendy; Dara G. Torgerson | Zendy; Christopher R. Gignoux | Zendy; Noah Zaitlen | Zendy; Celeste Eng | Zendy; William Rodríguez-Cintrón | Zendy; Rocío Chapela | Zendy; Jean G. Ford | Zendy; Pedro C. Avila | Zendy; José RodríguezSantana | Zendy; Gary K. Chen | Zendy; Loı̈c Le Marchand | Zendy; Brian E. Henderson | Zendy; David Reich | Zendy; Christopher A. Haiman | Zendy; Esteban G. Burchard | Zendy; Eran Halperin | Zendy

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Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation

Author(s) -

Bogdan Paşaniuc,

Sriram Sankararaman,

Dara G. Torgerson,

Christopher R. Gignoux,

Noah Zaitlen,

Celeste Eng,

William Rodríguez-Cintrón,

Rocío Chapela,

Jean G. Ford,

Pedro C. Avila,

José RodríguezSantana,

Gary K. Chen,

Loı̈c Le Marchand,

Brian E. Henderson,

David Reich,

Christopher A. Haiman,

Esteban G. Burchard,

Eran Halperin

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt166

Subject(s) - inference , genetic genealogy , ancestry informative marker , mendelian inheritance , biology , haplotype , population , genetics , evolutionary biology , multiple comparisons problem , covariate , 1000 genomes project , genotype , demography , statistics , allele frequency , single nucleotide polymorphism , computer science , gene , mathematics , artificial intelligence , sociology

Local ancestry analysis of genotype data from recently admixed populations (e.g. Latinos, African Americans) provides key insights into population history and disease genetics. Although methods for local ancestry inference have been extensively validated in simulations (under many unrealistic assumptions), no empirical study of local ancestry accuracy in Latinos exists to date. Hence, interpreting findings that rely on local ancestry in Latinos is challenging.

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