Sorad: a systems biology approach to predict and modulate dynamic signaling pathway response from phosphoproteome time-course measurements | Zendy

Tarmo Äijö | Zendy; Kirsi J. Granberg | Zendy; Harri Lähdesmäki | Zendy

Open Access

Sorad: a systems biology approach to predict and modulate dynamic signaling pathway response from phosphoproteome time-course measurements

Author(s) -

Tarmo Äijö,

Kirsi J. Granberg,

Harri Lähdesmäki

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt130

Subject(s) - systems biology , computational biology , signal transduction , computer science , pathway analysis , biology , microbiology and biotechnology , biochemistry , gene expression , gene

Signaling networks mediate responses to different stimuli using a multitude of feed-forward, feedback and cross-talk mechanisms, and malfunctions in these mechanisms have an important role in various diseases. To understand a disease and to help discover novel therapeutic approaches, we have to reveal the molecular mechanisms underlying signal transduction and use that information to design targeted perturbations.

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