Open AccessMitoSeek: extracting mitochondria information and performing high-throughput mitochondria sequencing analysis
Author(s) -
Yan Guo,
Jiang Li,
Chung-I Li,
Yu Shyr,
David C. Samuels
Publication year - 2013
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btt118
Subject(s) - heteroplasmy , genome , exome sequencing , mitochondrial dna , exome , biology , computational biology , genetics , reference genome , mitochondrion , cancer genome sequencing , genomics , mutation , gene
Exome capture kits have capture efficiencies that range from 40 to 60%. A significant amount of off-target reads are from the mitochondrial genome. These unintentionally sequenced mitochondrial reads provide unique opportunities to study the mitochondria genome.
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