mRNAStab—a web application for mRNA stability analysis | Zendy

Andy S. Alic | Zendy; José E. PérezOrtín | Zendy; Joaquín Moreno | Zendy; Vicente Arnau | Zendy

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mRNAStab—a web application for mRNA stability analysis

Author(s) -

Andy S. Alic,

José E. PérezOrtín,

Joaquín Moreno,

Vicente Arnau

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt040

Subject(s) - messenger rna , transcription (linguistics) , computational biology , software , computer science , gene expression , functional genomics , genomics , software package , gene , biology , bioinformatics , genetics , genome , operating system , linguistics , philosophy

Eukaryotic gene expression is regulated both at the transcription and the mRNA degradation levels. The implementation of functional genomics methods that allow the simultaneous measurement of transcription (TR) and degradation (DR) rates for thousands of mRNAs is a huge improvement in this field. One of the best established methods for mRNA stability determination is genomic run-on (GRO). It allows the measurement of DR, TR and mRNA levels during cell dynamic responses. Here, we offer a software package that provides improved algorithms for determination of mRNA stability during dynamic GRO experiments.

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