Genome Fusion Detection: a novel method to detect fusion genes from SNP-array data | Zendy

Sebastian Thieme | Zendy; Philip Groth | Zendy

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Genome Fusion Detection: a novel method to detect fusion genes from SNP-array data

Author(s) -

Sebastian Thieme,

Philip Groth

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt028

Subject(s) - fusion gene , snp array , computational biology , gene , biology , copy number variation , genome , genetics , single nucleotide polymorphism , genotype

Fusion genes result from genomic rearrangements, such as deletions, amplifications and translocations. Such rearrangements can also frequently be observed in cancer and have been postulated as driving event in cancer development. to detect them, one needs to analyze the transition region of two segments with different copy number, the location where fusions are known to occur. Finding fusion genes is essential to understanding cancer development and may lead to new therapeutic approaches.

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