A coherent feedforward loop design principle to sustain robustness of biological networks | Zendy

DucHau Le | Zendy; YungKeun Kwon | Zendy

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A coherent feedforward loop design principle to sustain robustness of biological networks

Author(s) -

DucHau Le,

YungKeun Kwon

Publication year - 2013

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btt026

Subject(s) - robustness (evolution) , feed forward , computer science , biological network , gene regulatory network , biological system , network topology , feedback loop , systems biology , distributed computing , control theory (sociology) , control (management) , artificial intelligence , control engineering , biology , gene , computational biology , engineering , computer network , biochemistry , gene expression , computer security

Many studies have investigated the relationship between structural properties and dynamic behaviors in biological networks. In particular, feedback loop (FBL) and feedforward loop (FFL) structures have received a great deal of attention. One interesting and common property of FBL and FFL structures is their coherency of coupling. However, the role of coherent FFLs in relation to network robustness is not fully known, whereas that of coherent FBLs has been well established.

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