A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data | Zendy

Andrew E. Teschendorff | Zendy; Francesco Marabita | Zendy; Matthias Lechner | Zendy; Thomas E. Bartlett | Zendy; Jesper Tegnér | Zendy; David Gómez-Cabrero | Zendy; Stephan Beck | Zendy

Open Access

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

Author(s) -

Andrew E. Teschendorff,

Francesco Marabita,

Matthias Lechner,

Thomas E. Bartlett,

Jesper Tegnér,

David Gómez-Cabrero,

Stephan Beck

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts680

Subject(s) - normalization (sociology) , dna methylation , preprocessor , computer science , computational biology , data mining , biology , genetics , artificial intelligence , gene , gene expression , sociology , anthropology

The Illumina Infinium 450 k DNA Methylation Beadchip is a prime candidate technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated with these beadarrays is that probes come in two different designs, characterized by widely different DNA methylation distributions and dynamic range, which may bias downstream analyses. A key statistical issue is therefore how best to adjust for the two different probe designs.

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