Open AccessMycPermCheck: the Mycobacterium tuberculosis permeability prediction tool for small molecules
Author(s) -
Benjamin Merget,
David Zilian,
Tobias Müller,
Christoph Sotriffer
Publication year - 2012
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bts641
Subject(s) - antimycobacterial , mycobacterium tuberculosis , tuberculosis , computer science , virtual screening , small molecule , computational biology , drug discovery , chemistry , bioinformatics , medicine , biology , biochemistry , pathology
With >8 million new cases in 2010, particularly documented in developing countries, tuberculosis (TB) is still a highly present pandemic and often terminal. This is also due to the emergence of antibiotic-resistant strains (MDR-TB and XDR-TB) of the primary causative TB agent Mycobacterium tuberculosis (MTB). Efforts to develop new effective drugs against MTB are restrained by the unique and largely impermeable composition of the mycobacterial cell wall.
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