DAFS: simultaneous aligning and folding of RNA sequences via dual decomposition | Zendy

Kengo Sato | Zendy; Yuki Kato | Zendy; Tatsuya Akutsu | Zendy; Kiyoshi Asai | Zendy; Yasubumi Sakakibara | Zendy

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DAFS: simultaneous aligning and folding of RNA sequences via dual decomposition

Author(s) -

Kengo Sato,

Yuki Kato,

Tatsuya Akutsu,

Kiyoshi Asai,

Yasubumi Sakakibara

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts612

Subject(s) - pairwise comparison , structural alignment , protein secondary structure , computer science , nucleic acid secondary structure , multiple sequence alignment , consistency (knowledge bases) , sequence (biology) , sequence alignment , dual (grammatical number) , computational biology , algorithm , data mining , rna , artificial intelligence , biology , genetics , peptide sequence , biochemistry , gene , art , literature

It is well known that the accuracy of RNA secondary structure prediction from a single sequence is limited, and thus a comparative approach that predicts a common secondary structure from aligned sequences is a better choice if homologous sequences with reliable alignments are available. However, correct secondary structure information is needed to produce reliable alignments of RNA sequences. To tackle this dilemma, we require a fast and accurate aligner that takes structural information into consideration to yield reliable structural alignments, which are suitable for common secondary structure prediction.

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