Assessing the relationship between conservation of function and conservation of sequence using photosynthetic proteins | Zendy

Shaul Ashkenazi | Zendy; Rotem Snir | Zendy; Yanay Ofran | Zendy

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Assessing the relationship between conservation of function and conservation of sequence using photosynthetic proteins

Author(s) -

Shaul Ashkenazi,

Rotem Snir,

Yanay Ofran

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts608

Subject(s) - function (biology) , photosynthesis , sequence (biology) , biology , similarity (geometry) , conserved sequence , computational biology , evolutionary biology , genetics , computer science , peptide sequence , botany , gene , artificial intelligence , image (mathematics)

Assessing the false positive rate of function prediction methods is difficult, as it is hard to establish that a protein does not have a certain function. To determine to what extent proteins with similar sequences have a common function, we focused on photosynthesis-related proteins. A protein that comes from a non-photosynthetic organism is, undoubtedly, not involved in photosynthesis.

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