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Gene and translation initiation site prediction in metagenomic sequences
Author(s) -
Doug Hyatt,
Philip LoCascio,
Loren Hauser,
Edward C. Uberbacher
Publication year - 2012
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bts429
Subject(s) - metagenomics , gene prediction , computer science , source code , software , genome , identification (biology) , data mining , computational biology , dna sequencing , gene , coding (social sciences) , biology , genetics , statistics , mathematics , programming language , botany
Gene prediction in metagenomic sequences remains a difficult problem. Current sequencing technologies do not achieve sufficient coverage to assemble the individual genomes in a typical sample; consequently, sequencing runs produce a large number of short sequences whose exact origin is unknown. Since these sequences are usually smaller than the average length of a gene, algorithms must make predictions based on very little data.

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