Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration | Zendy

Amit Singh | Zendy; Juliascimento | Zendy; Silke Kowar | Zendy; Hauke Busch | Zendy; Melanie Boerries | Zendy

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Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration

Author(s) -

Amit Singh,

Juliascimento,

Silke Kowar,

Hauke Busch,

Melanie Boerries

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts410

Subject(s) - autocrine signalling , hepatocyte growth factor , hepatocyte growth factor receptor , biology , signalling , cell migration , gene regulatory network , microbiology and biotechnology , computational biology , computer science , c met , receptor , cell , gene , genetics , gene expression

Cell migration is a complex process that is controlled through the time-sequential feedback regulation of protein signalling and gene regulation. Based on prior knowledge and own experimental data, we developed a large-scale dynamic network describing the onset and maintenance of hepatocyte growth factor-induced migration of primary human keratinocytes. We applied Boolean logic to capture the qualitative behaviour as well as short-and long-term dynamics of the complex signalling network involved in this process, comprising protein signalling, gene regulation and autocrine feedback.

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