Inferring epigenetic and transcriptional regulation during blood cell development with a mixture of sparse linear models | Zendy

Thaís G. do Rêgo | Zendy; Helge G. Roider | Zendy; Francisco A. T. de Carvalho | Zendy; Ivan G. Costa | Zendy

Open Access

Inferring epigenetic and transcriptional regulation during blood cell development with a mixture of sparse linear models

Author(s) -

Thaís G. do Rêgo,

Helge G. Roider,

Francisco A. T. de Carvalho,

Ivan G. Costa

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts362

Subject(s) - chromatin , epigenetics , histone , transcription factor , cell fate determination , computational biology , cell type , cell , biology , gene expression , regulation of gene expression , epigenesis , transcriptional regulation , gene , genetics , dna methylation

Blood cell development is thought to be controlled by a circuit of transcription factors (TFs) and chromatin modifications that determine the cell fate through activating cell type-specific expression programs. To shed light on the interplay between histone marks and TFs during blood cell development, we model gene expression from regulatory signals by means of combinations of sparse linear regression models.

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