A common ancestry for BAP1 and Uch37 regulators | Zendy

Luis SánchezPulido | Zendy; Lesheng Kong | Zendy; Chris P. Ponting | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A common ancestry for BAP1 and Uch37 regulators

Author(s) -

Luis SánchezPulido,

Lesheng Kong,

Chris P. Ponting

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts319

Subject(s) - deubiquitinating enzyme , biology , ubiquitin , chromatin , microbiology and biotechnology , computational biology , binding site , genetics , gene

To reveal how the polycomb repressive-deubiquitinase (PR-DUB) complex controls substrate selection specificity, we undertook a detailed computational sequence analysis of its components: additional sex combs like 1 (ASXL1) and BRCA1-associated protein 1 (BAP1) proteins. This led to the discovery of two previously unrecognized domains in ASXL1: a forkhead (winged-helix) DNA-binding domain and a deubiquitinase adaptor domain shared with two regulators of ubiquitin carboxyl-terminal hydrolase 37 (Uch37), namely adhesion regulating molecule 1 (ADRM1) and nuclear factor related to kappaB (NFRKB). Our analysis demonstrates a common ancestry for BAP1 and Uch37 regulators in PR-DUB, INO80 chromatin remodelling and proteosome complexes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research