Efficient RNA pairwise structure comparison by SETTER method
Author(s) -
David Hoksza,
Daniel Svozil
Publication year - 2012
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bts301
Subject(s) - setter , pairwise comparison , similarity (geometry) , computer science , structural similarity , structural alignment , data mining , artificial intelligence , algorithm , computational biology , pattern recognition (psychology) , sequence alignment , biology , image (mathematics) , biochemistry , genetics , gene , peptide sequence
Understanding the architecture and function of RNA molecules requires methods for comparing and analyzing their 3D structures. Although a structural alignment of short RNAs is achievable in a reasonable amount of time, large structures represent much bigger challenge. However, the growth of the number of large RNAs deposited in the PDB database calls for the development of fast and accurate methods for analyzing their structures, as well as for rapid similarity searches in databases.
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