Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs | Zendy

Christopher T. Saunders | Zendy; Wendy S.W. Wong | Zendy; Sajani Swamy | Zendy; Jennifer Becq | Zendy; Lisa Murray | Zendy; R. Keira Cheetham | Zendy

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Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

Author(s) -

Christopher T. Saunders,

Wendy S.W. Wong,

Sajani Swamy,

Jennifer Becq,

Lisa Murray,

R. Keira Cheetham

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts271

Subject(s) - indel , biology , somatic cell , exome sequencing , computational biology , genotype , genome , genetics , allele frequency , computer science , mutation , single nucleotide polymorphism , gene

Whole genome and exome sequencing of matched tumor-normal sample pairs is becoming routine in cancer research. The consequent increased demand for somatic variant analysis of paired samples requires methods specialized to model this problem so as to sensitively call variants at any practical level of tumor impurity.

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