Semantic integration of physiology phenotypes with an application to the Cellular Phenotype Ontology | Zendy

Robert Hoehndorf | Zendy; Midori A. Harris | Zendy; Heinrich Herre | Zendy; Gabriella Rustici | Zendy; Georgios V. Gkoutos | Zendy

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Semantic integration of physiology phenotypes with an application to the Cellular Phenotype Ontology

Author(s) -

Robert Hoehndorf,

Midori A. Harris,

Heinrich Herre,

Gabriella Rustici,

Georgios V. Gkoutos

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts250

Subject(s) - phenotype , ontology , computer science , computational biology , semantic integration , biology , world wide web , semantic web , genetics , gene , semantic computing , epistemology , philosophy

The systematic observation of phenotypes has become a crucial tool of functional genomics, and several large international projects are currently underway to identify and characterize the phenotypes that are associated with genotypes in several species. To integrate phenotype descriptions within and across species, phenotype ontologies have been developed. Applying ontologies to unify phenotype descriptions in the domain of physiology has been a particular challenge due to the high complexity of the underlying domain.

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