Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development | Zendy

Tavis K. Anderson | Zendy; William W. Laegreid | Zendy; Francesco Cerutti | Zendy; Fernando A. Osorio | Zendy; Eric Nelson | Zendy; Jane ChristopherHennings | Zendy; Tony L. Goldberg | Zendy

Open Access

Ranking viruses: measures of positional importance within networks define core viruses for rational polyvalent vaccine development

Author(s) -

Tavis K. Anderson,

William W. Laegreid,

Francesco Cerutti,

Fernando A. Osorio,

Eric Nelson,

Jane ChristopherHennings,

Tony L. Goldberg

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts181

Subject(s) - biology , computational biology , in silico , viral evolution , ranking (information retrieval) , virology , genetics , rna , gene , computer science , artificial intelligence

The extraordinary genetic and antigenic variability of RNA viruses is arguably the greatest challenge to the development of broadly effective vaccines. No single viral variant can induce sufficiently broad immunity, and incorporating all known naturally circulating variants into one multivalent vaccine is not feasible. Furthermore, no objective strategies currently exist to select actual viral variants that should be included or excluded in polyvalent vaccines.

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