PhyLAT: a phylogenetic local alignment tool | Zendy

Hongtao Sun | Zendy; Jeremy Buhler | Zendy

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PhyLAT: a phylogenetic local alignment tool

Author(s) -

Hongtao Sun,

Jeremy Buhler

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts158

Subject(s) - multiple sequence alignment , genome , phylogenetic tree , alignment free sequence analysis , pairwise comparison , smith–waterman algorithm , sequence alignment , computer science , computational biology , biology , data mining , genetics , gene , artificial intelligence , peptide sequence

The expansion of DNA sequencing capacity has enabled the sequencing of whole genomes from a number of related species. These genomes can be combined in a multiple alignment that provides useful information about the evolutionary history at each genomic locus. One area in which evolutionary information can productively be exploited is in aligning a new sequence to a database of existing, aligned genomes. However, existing high-throughput alignment tools are not designed to work effectively with multiple genome alignments.

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