FTEC: a coalescent simulator for modeling faster than exponential growth | Zendy

Mark Reppell | Zendy; Michael Boehnke | Zendy; Sebastian Zöllner | Zendy

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FTEC: a coalescent simulator for modeling faster than exponential growth

Author(s) -

Mark Reppell,

Michael Boehnke,

Sebastian Zöllner

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts135

Subject(s) - coalescent theory , computer science , exponential function , exponential growth , simulation , computer graphics (images) , mathematics , biology , mathematical analysis , gene , phylogenetic tree , biochemistry

Recent genetic studies as well as recorded history point to massive growth in human population sizes during the recent past. To model and understand this growth accurately we introduce FTEC, an easy-to-use coalescent simulation program capable of simulating haplotype samples drawn from a population that has undergone faster than exponential growth. Samples drawn from a population that has undergone faster than exponential growth show an excess of very rare variation and more rapid LD decay when compared with samples drawn from a population that has maintained a constant size over time.

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