Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data | Zendy

Yuan Yuan | Zendy; Yanxun Xu | Zendy; Jianfeng Xu | Zendy; Robyn L. Ball | Zendy; Han Liang | Zendy

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Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data

Author(s) -

Yuan Yuan,

Yanxun Xu,

Jianfeng Xu,

Robyn L. Ball,

Han Liang

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts120

Subject(s) - phenotype , gene knockout , knockout mouse , computational biology , gene , biology , genetics , set (abstract data type) , conditional gene knockout , genomics , computer science , genome , programming language

The phenotypes of knockout mice provide crucial information for understanding the biological functions of mammalian genes. Among various knockout phenotypes, lethality is of great interest because those involved genes play essential roles. With the availability of large-scale genomic data, we aimed to assess how well the integration of various genomic features can predict the lethal phenotype of single-gene knockout mice.

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