A new statistical approach to detecting differentially methylated loci for case control Illumina array methylation data | Zendy

Zhongxue Chen | Zendy; Qingzhong Liu | Zendy; Saralees Nadarajah | Zendy

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A new statistical approach to detecting differentially methylated loci for case control Illumina array methylation data

Author(s) -

Zhongxue Chen,

Qingzhong Liu,

Saralees Nadarajah

Publication year - 2012

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bts093

Subject(s) - dna methylation , epigenetics , methylation , computational biology , biology , genetics , gene , computer science , gene expression

As an epigenetic alteration, DNA methylation plays an important role in epigenetic controls of gene transcription. Recent advances in genome-wide scan of DNA methylation provide great opportunities in studying the impact of DNA methylation on many human diseases including various types of cancer. Due to the unique feature of this type of data, applicable statistical methods are limited and new sophisticated approaches are desirable.

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