IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data
Author(s) -
Dan Wang,
Li Yan,
Qiang Hu,
Lara E. Sucheston,
Michael J. Higgins,
Christine B. Ambrosone,
Candace S. Johnson,
Dominic J. Smiraglia,
Song Liu
Publication year - 2012
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bts013
Subject(s) - methylation , dna methylation , illumina methylation assay , computational biology , epigenetics , automatic summarization , cpg site , computer science , pipeline (software) , illumina dye sequencing , biology , genetics , dna sequencing , gene , operating system , gene expression , information retrieval
The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human genome. Illumina Methylation Analyzer (IMA) is a computational package designed to automate the pipeline for exploratory analysis and summarization of site-level and region-level methylation changes in epigenetic studies utilizing the 450K DNA methylation microarray. The pipeline loads the data from Illumina platform and provides user-customized functions commonly required to perform exploratory methylation analysis for individual sites as well as annotated regions.
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