NRPSsp: non-ribosomal peptide synthase substrate predictor | Zendy

Carlos Alberto Vanegas Prieto | Zendy; Carlos GarcíaEstrada | Zendy; Diego Lorenzana | Zendy; Juan F. Martı́n | Zendy

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NRPSsp: non-ribosomal peptide synthase substrate predictor

Author(s) -

Carlos Alberto Vanegas Prieto,

Carlos GarcíaEstrada,

Diego Lorenzana,

Juan F. Martı́n

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr659

Subject(s) - ribosomal rna , substrate (aquarium) , atp synthase , peptide , chemistry , biochemistry , computational biology , computer science , biology , enzyme , ecology , gene

Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes, which biosynthesize many important peptide compounds produced by bacteria and fungi. Some studies have revealed that an individual domain within the NRPSs shows significant substrate selectivity. The discovery and characterization of non-ribosomal peptides are of great interest for the biotechnological industries. We have applied computational mining methods in order to build a database of NRPSs modules that bind to specific substrates. We have used this database to build a hidden Markov model predictor of substrates that bind to a given NRPS.

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