Inferring sequence regions under functional divergence in duplicate genes | Zendy

Yi-Fei Huang | Zendy; G. Brian Golding | Zendy

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Inferring sequence regions under functional divergence in duplicate genes

Author(s) -

Yi-Fei Huang,

G. Brian Golding

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr635

Subject(s) - functional divergence , divergence (linguistics) , biology , gene duplication , phylogenetic tree , computational biology , gene , genetics , evolutionary biology , gene family , genome , linguistics , philosophy

A number of statistical phylogenetic methods have been proposed to identify type-I functional divergence in duplicate genes by detecting heterogeneous substitution rates in phylogenetic trees. A common disadvantage of the existing methods is that autocorrelation of substitution rates along sequences is not modeled. This reduces the power of existing methods to identify regions under functional divergence.

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