Open AccessPRINCIPLE: a tool for associating genes with diseases via network propagation
Author(s) -
Assaf Gottlieb,
Oded Magger,
Igor Berman,
Eytan Ruppin,
Roded Sharan
Publication year - 2011
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btr584
Subject(s) - computer science , computational biology , gene , theoretical computer science , genetics , artificial intelligence , biology
PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease.
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