ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression | Zendy

J Engreitz | Zendy; Rong Chen | Zendy; Alexander A. Morgan | Zendy; Joel T. Dudley | Zendy; Rohan Mallelwar | Zendy; Atul J. Butte | Zendy

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ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression

Author(s) -

J Engreitz,

Rong Chen,

Alexander A. Morgan,

Joel T. Dudley,

Rohan Mallelwar,

Atul J. Butte

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr548

Subject(s) - microarray databases , expression (computer science) , computer science , genome , differential (mechanical device) , computational biology , microarray analysis techniques , data mining , information retrieval , gene expression , biology , gene , genetics , engineering , programming language , aerospace engineering

We introduce ProfileChaser, a web server that allows for querying the Gene Expression Omnibus based on genome-wide patterns of differential expression. Using a novel, content-based approach, ProfileChaser retrieves expression profiles that match the differentially regulated transcriptional programs in a user-supplied experiment. This analysis identifies statistical links to similar expression experiments from the vast array of publicly available data on diseases, drugs, phenotypes and other experimental conditions.

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