SpliceTrap: a method to quantify alternative splicing under single cellular conditions | Zendy

Jie Wu | Zendy; Martin Akerman | Zendy; Shuying Sun | Zendy; W. Richard McCombie | Zendy; Adrian R. Krainer | Zendy; Michael Q. Zhang | Zendy

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SpliceTrap: a method to quantify alternative splicing under single cellular conditions

Author(s) -

Jie Wu,

Martin Akerman,

Shuying Sun,

W. Richard McCombie,

Adrian R. Krainer,

Michael Q. Zhang

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr508

Subject(s) - exon , alternative splicing , rna splicing , computational biology , robustness (evolution) , computer science , exon skipping , biology , bayesian probability , inference , gene , rna , genetics , artificial intelligence

Alternative splicing (AS) is a pre-mRNA maturation process leading to the expression of multiple mRNA variants from the same primary transcript. More than 90% of human genes are expressed via AS. Therefore, quantifying the inclusion level of every exon is crucial for generating accurate transcriptomic maps and studying the regulation of AS.

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