Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty | Zendy

Anthony R. Soltis | Zendy; Jeffrey J. Saucerman | Zendy

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Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty

Author(s) -

Anthony R. Soltis,

Jeffrey J. Saucerman

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr496

Subject(s) - robustness (evolution) , computer science , complex network , biological network , biological system , biology , computational biology , genetics , gene , world wide web

Biological networks are robust to a wide variety of internal and external perturbations, yet fragile or sensitive to a small minority of perturbations. Due to this rare sensitivity of networks to certain perturbations, it is unclear how precisely biochemical parameters must be experimentally measured in order to accurately predict network function.

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