cSSMD: assessing collective activity for addressing off-target effects in genome-scale RNA interference screens | Zendy

Xiaohua Douglas Zhang | Zendy; Francesca Santini | Zendy; Raul Lacson | Zendy; Shane Marine | Zendy; Qian Wu | Zendy; Luca Benetti | Zendy; Ruojing Yang | Zendy; Alex McCampbell | Zendy; Joel P. Berger | Zendy; Dawn Toolan | Zendy; Erica Stec | Zendy; Daniel Holder | Zendy; Keith A. Soper | Zendy; Joseph F. Heyse | Zendy; Marc Ferrer | Zendy

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cSSMD: assessing collective activity for addressing off-target effects in genome-scale RNA interference screens

Author(s) -

Xiaohua Douglas Zhang,

Francesca Santini,

Raul Lacson,

Shane Marine,

Qian Wu,

Luca Benetti,

Ruojing Yang,

Alex McCampbell,

Joel P. Berger,

Dawn Toolan,

Erica Stec,

Daniel Holder,

Keith A. Soper,

Joseph F. Heyse,

Marc Ferrer

Publication year - 2011

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btr474

Subject(s) - rna interference , computational biology , interference (communication) , computer science , small interfering rna , false positive paradox , gene , rna , biology , genetics , artificial intelligence , computer network , channel (broadcasting)

Off-target activity commonly exists in RNA interference (RNAi) screens and often generates false positives. Existing analytic methods for addressing the off-target effects are demonstrably inadequate in RNAi confirmatory screens.

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